Pradimicin S, a new pradimicin analog. II. Isolation and structure elucidation.
نویسندگان
چکیده
Pradimicin S was isolated from the culture filtrate of Actinomadura spinosa AA0851. NMR and MS analyses proved that pradimicin S is the 3'-O-(3''-O-sulfo-beta-D-glucopyranosyl) analog of pradimicin A, a new member of the pradimicin family of antibiotics. Stereochemical assignment was made by correlating pradimicin S with pradimicin L.
منابع مشابه
Biosynthesis of the pradimicin family of antibiotics. II. Fermentation, isolation and structure determination of metabolites associated with the pradimicins biosynthesis.
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متن کاملSynthesis and antifungal activities of pradimicin A derivatives modification of the alanine moiety.
Chemical modifications of the carboxyl group in the alanine moiety of pradimicin A were performed and in vitro and in vivo antifungal activities of the derivatives were examined in comparison with those of pradimicin A. The amide derivatives showed activities comparable to pradimicin A, indicating that the free carboxyl group can be modified without impairing the antifungal activity.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 46 3 شماره
صفحات -
تاریخ انتشار 1993